S100B

Also known as NEF, S100, S100-B, S100beta, S100 calcium binding protein B

S100 calcium-binding protein B (S100B) is a protein of the S100 protein family.

Gene data

S100B

Name: S100 calcium binding protein B
Type: protein-coding
Position: 46,598,355–46,605,208 (−)
Aliases: NEF, S100, S100-B, S100beta
Ensembl: ENSG00000160307
RefSeq RNA: NM_006272.3, XM_017028424.3, XM_054324737.1
RefSeq protein: NP_006263.1, XP_016883913.1, XP_054180712.1

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008].

Pathways

Signaling by ERBB4 Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signal Transduction Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor 9 (TLR9) Cascade Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade

via MyGene.info

Gene · Ensembl

S100 calcium binding protein B

Symbol: S100B
Biotype: Protein coding
Organism: Homo sapiens
Location: 21:46,598,355-46,605,208
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~4 min read

Encyclopedic overview

6 sections

Contents

Function
Clinical significance
Diagnostic use
Interactions
References
Further reading

S100 calcium-binding protein B (S100B) is a protein of the S100 protein family.

S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3.

Excerpted from Wikipedia’s “S100B” article, available under the CC BY-SA 4.0 licence.