iron overload
Sign in to saveAlso known as hereditary haemochromatosis, iron overload (disorder), obsolete iron overload
human disease
OverviewAI-generated
Iron overload is a medical condition classified under the category of hemochromatosis. It is identified in the International Classification of Diseases, 10th Revision, as an abnormal level of blood mineral. The condition is associated with specific database identifiers, including the NCI Thesaurus ID C78393 and the Disease Ontology ID DOID:2350.
Research and clinical data regarding iron overload are extensive. A search of the PubMed database yields 24,221 entries for the query "iron overload." Additionally, ClinicalTrials.gov lists 238 studies related to the condition. The topic is also referenced by 600 other encyclopedia articles.
Synthesized by Vinony from 9 facts across 5 sources: Wikidata, PubMed, ClinicalTrials.gov, Medline, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Specialty
- Hematology , gastroenterology / hepatology
via Wikipedia infobox
Health references
- ICD-10
- R79.0 — Abnormal level of blood mineral
- MedlinePlus
- Consumer health page →
Research
24,221 papers- The Evaluation of Iron Deficiency and Iron Overload.Deutsches Arzteblatt international · 2021
- The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis.Biomolecules · 2022
- Iron overload: The achilles heel of β-thalassemia.Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine · 2024
- [Hepatic iron overload].Annales de pathologie · 2024
- Iron overload in myelodysplastic syndromes (MDS).International journal of hematology · 2018
via PubMed
Clinical Trials
238 registered- PHASE2COMPLETEDEvaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron OverloadNovartis Pharmaceuticals · NCT00600938
- NATERMINATEDDeferoxamine for Iron Overload Before Allogeneic Stem Cell TransplantationDana-Farber Cancer Institute · NCT00658411
- PHASE2COMPLETEDStudy of Deferasirox Relative to Subcutaneous Deferoxamine in Sickle Cell Disease PatientsNovartis Pharmaceuticals · NCT00110617
- PHASE4COMPLETEDEvaluating the Efficacy of Deferasirox in Transfusion Dependent Chronic Anaemias (Myelodysplastic Syndrome, Beta-thalassaemia Patients) With Chronic Iron OverloadNovartis Pharmaceuticals · NCT00564941
- NAUNKNOWNQuality and Biologic Characteristics of Red Blood Concentrates Obtained From Individuals With Elevated Ferritin.Interregionale Blutspende SRK · NCT05742035
- PHASE3COMPLETEDA Study of Long-term Treatment With Deferasirox in Patients With Beta-thalassemia and Transfusional HemosiderosisNovartis · NCT00171171
~22 min read
Encyclopedic overview
Iron overload is the abnormal and increased accumulation of total iron in the body, leading to organ damage. The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction. Iron overload is often primary (i.e., hereditary haemochromatosis, aceruloplasminemia) but may also be secondary to other causes (i.e., transfusional iron overload). Iron deposition most commonly occurs in the liver, pancreas, skin, heart, and joints.
People with iron overload classically present with the triad of liver cirrhosis, secondary diabetes mellitus, and bronze skin. However, due to earlier detection nowadays, symptoms are often limited to general chronic malaise, arthralgia, and hepatomegaly.
Excerpted from Wikipedia’s “iron overload” article, available under the CC BY-SA 4.0 licence.