Structure via PubChem · Public domain (PubChem)
ایزوسوربید
Sign in to saveAlso known as Isosorbide
Isosorbide is a bicyclic chemical compound from the group of diols and the oxygen-containing heterocycles, containing two fused furan rings. The starting material for isosorbide is D-sorbitol, which is obtained by catalytic hydrogenation of D-glucose, which is in turn produced by hydrolysis of starch. Isosorbide is discussed as a plant-based platform chemical from which biodegradable derivatives of various functionality can be obtained.
Key facts
- Drug.tradename
- Ismotic, Isobide, others
- Drug.DailyMedID
- Isosorbide
via Wikipedia infobox
Chemical data
- Formula
- C6H10O4
- Molecular weight
- 146.14 g/mol
- IUPAC name
- (3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol
- SMILES
- C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)O)O
- InChIKey
- KLDXJTOLSGUMSJ-JGWLITMVSA-N
- XLogP
- -1.4
- Polar surface area
- 58.9 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1974
- Admin. routes
- oral
- Indications
- chronic lymphocytic leukemia, angina pectoris, head and neck squamous cell carcinoma, diffuse large B-cell lymphoma
via ChEMBL · EBI
Research
5,266 papers- Long-acting isosorbide mononitrate.Drugs · 1999
- Isosorbide Diesters: Mechanistic Insights and Therapeutic Applications in Skin and Neuroinflammatory Disorders.International journal of molecular sciences · 2025
- Isosorbide and nifedipine for Chagas' megaesophagus: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2018
- Pharmacokinetics of isosorbide mononitrate.The American journal of cardiology · 1992
- Misoprostol plus isosorbide mononitrate versus misoprostol alone for cervical ripening during labor induction: A systematic review and meta-analysis of randomized controlled trials.Journal of gynecology obstetrics and human reproduction · 2022
via PubMed
Wikidata facts
- Has part
- hydrogen
- Mass
- 146.058
- Has use
- medication
Show 7 more facts
- significant drug interaction
- vardenafil
- chemical formula
- C₆H₁₀O₄
- isomeric SMILES
- C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)O)O
- canonical SMILES
- C1C(C2C(O1)C(CO2)O)O
- medical condition treated
- gastroesophageal reflux disease
- Commons category
- Isosorbide
- melting point
- 60
via Wikidata · CC0