JMJD1C
Sign in to saveAlso known as TRIP8, TRIP-8, jumonji domain containing 1C, KDM3C
Jumonji domain containing 1C is a protein that in humans is encoded by the JMJD1C gene.
Gene data
JMJD1C- Name
- jumonji domain containing 1C
- Type
- protein-coding
- Aliases
- KDM3C, TRIP-8, TRIP8
The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
via MyGene.info
Gene · Ensembl
jumonji domain containing 1C
- Symbol
- JMJD1C
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:63,167,221-63,521,850
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 3129
- genetic association
- juvenile rheumatoid arthritis
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/221037
- genomic end
- 65225722
- genomic start
- 64926981
- chromosome
- human chromosome 10
- cytogenetic location
- 10q21.3
- expressed in
- testicle
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Epigenetic regulation of spermatogenesis
- References
- Further reading
Jumonji domain containing 1C is a protein that in humans is encoded by the JMJD1C gene.
==Function==
Excerpted from Wikipedia’s “JMJD1C” article, available under the CC BY-SA 4.0 licence.