USF1

Also known as FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11, upstream transcription factor 1

Upstream stimulatory factor 1 is a protein that in humans is encoded by the USF1 gene.

Gene data

USF1

Name: upstream transcription factor 1
Type: protein-coding
Position: 161,039,249–161,045,982 (−)
Aliases: FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11
Ensembl: ENSG00000158773
RefSeq RNA: NM_001276373.2, NM_007122.5, NM_207005.3, XM_047429959.1, XM_054338612.1
RefSeq protein: NP_001263302.1, NP_009053.1, NP_996888.1, XP_047285915.1, XP_054194587.1

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013].

Gene Ontology

Biological process

response to hypoxia glucose metabolic process regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II response to UV response to UV glucose mediated signaling pathway

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

chromatin chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm transcription regulator complex

Pathways

Developmental Biology Signal Transduction ESR-mediated signaling Signaling by Nuclear Receptors Estrogen-dependent gene expression MITF-M-regulated melanocyte development Regulation of MITF-M-dependent genes involved in pigmentation MITF-M-dependent gene expression

via MyGene.info

Gene · Ensembl

upstream transcription factor 1

Symbol: USF1
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:161,039,249-161,045,982
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~19 min read

Encyclopedic overview

22 sections

Contents

Gene
Isoforms
Protein
Function
Regulation
Modulation of DNA binding affinity
Phosphorylation
Gene transcription
Chromosome boundary by USF
FASN transactivates for lipogenesis
Lipogenic pathways
In early embryonic development
Clinical significance
Diabetic kidney disease
Cancer
Increased FASN-mediated de novo lipid synthesis
Decreased USF1-p53 interaction and increased p53 instability
Familial combined hyperlipidemia
Interactions
References
Further reading
External links

Upstream stimulatory factor 1 is a protein that in humans is encoded by the USF1 gene.

== Gene == left|thumb|Representative illustration of bHLH motif binding to the consensus sequence on DNA

Excerpted from Wikipedia’s “USF1” article, available under the CC BY-SA 4.0 licence.

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USF1

Gene data

Gene Ontology

Pathways

Gene · Ensembl

Encyclopedic overview

Available in 5 languages

What links here821 pages

What links here821 pages