JWH-018
Sign in to saveJWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO or AM-678) is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use as synthetic cannabinoid products that, in some countries, are sold legally as "incense blends".
Key facts
- Drug.O
- 1
- Drug.H
- 23
- Drug.N
- 1
- Drug.Verifiedfields
- changed
- Drug.class
- Cannabinoid
- Drug.verifiedrevid
- 477168756
- Drug.IUPAC_name
- (Naphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone
- Drug.image
- JWH018.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- JWH-018 ball-and-stick model.png
- Drug.image_class2
- bg-transparent
- Drug.legal_AU
- S9
- Drug.legal_BR
- F2
- Drug.legal_UK
- Class B
- Drug.legal_US
- Schedule I
- Drug.legal_DE
- Anlage II
- Drug.legal_CA
- Schedule II, In general uncontrolled could be illegal to sell for human consumption or the analogue acts in several countries.
- Drug.legal_UN
- P II
via Wikipedia infobox
Research
356 papers- Effects of synthetic (JWH-018) cannabinoids treatment on spermatogenesis and sperm function.Drug and chemical toxicology · 2022
- JWH-018 impairs sensorimotor functions in mice.Neuroscience · 2015
- Synthetic cannabinoids JWH-018, JWH-122, UR-144 and the phytocannabinoid THC activate apoptosis in placental cells.Toxicology letters · 2020
- Ethanol enhances JWH-018-induced impairment of sensorimotor and memory functions in mice: From preclinical evidence to forensic implication in Driving Under the Influence of Drugs.Drug and alcohol dependence · 2023
- The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism.FEMS yeast research · 2019
via PubMed
~10 min read
Encyclopedic overview
11 sectionsContents
- History
- Pharmacology
- Pharmacokinetics
- Recreational use
- Detection in biological fluids
- Legal status
- Synthesis
- See also
- References
- Further reading
- External links
JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO or AM-678) is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use as synthetic cannabinoid products that, in some countries, are sold legally as "incense blends".
As a full agonist at both the CB1 and CB2 cannabinoid receptors, this chemical compound is classified as an analgesic medication. The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis.
Excerpted from Wikipedia’s “JWH-018” article, available under the CC BY-SA 4.0 licence.