Structure via PubChem · Public domain (PubChem)
magnolol
Sign in to saveMagnolol is an organic compound that is classified as lignan. It is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis) and in M. grandiflora.
Chemical data
- Formula
- C18H18O2
- Molecular weight
- 266.3 g/mol
- IUPAC name
- 2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol
- SMILES
- C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O
- InChIKey
- VVOAZFWZEDHOOU-UHFFFAOYSA-N
- XLogP
- 5
- Polar surface area
- 40.5 Ų
- H-bond donors
- 2
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
1,024 papers- Magnolol as a Potential Anticancer Agent: A Proposed Mechanistic Insight.Molecules (Basel, Switzerland) · 2022
- Magnolol improves Alzheimer's disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK/mTOR/ULK1 pathway.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
- Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer.International journal of molecular sciences · 2018
- Honokiol and magnolol: A review of structure-activity relationships of their derivatives.Phytochemistry · 2024
- Insights on the Multifunctional Activities of Magnolol.BioMed research international · 2019
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 266.131
Show 4 more facts
- canonical SMILES
- C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O
- chemical formula
- C₁₈H₁₈O₂
- subject has role
- platelet aggregation inhibitors
- found in taxon
- Magnolia obovata
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- Bioactivity
- References
- Further reading
Magnolol is an organic compound that is classified as lignan. It is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis) and in M. grandiflora.
Magnolol is a compound that acts on GABAA receptors and functions as an allosteric modulator. It has antifungal properties and demonstrates anti-periodontal disease effects in animal models. In cell cultures, magnolol stimulates osteoblasts and inhibits osteoclasts, indicating potential for anti-osteoporosis treatment. It also binds in a dimeric form to PPARγ, acting as an agonist of this nuclear receptor. Additionally, magnolol may interact with cannabinoid receptors, acting as a partial agonist of CB2 receptors with lower affinity for CB1 receptors.
Excerpted from Wikipedia’s “magnolol” article, available under the CC BY-SA 4.0 licence.