JWH-210
Sign in to saveJWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46 nM at CB1 and 0.69 nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologues JWH-122 (CB1 Ki 0.69 nM) and JWH-182 (CB1 Ki 0.65 nM) respectively, and than the 4-methoxy compound JWH-081 (CB1 Ki 1.2 nM). It was discovered by and named after John W. Huffman
In the Vinony graph
Vinony's link graph records 453 inbound references to JWH-210, and connects out to synthetic cannabinoid, synhexyl and digital object identifier.
Vinony files it under CB1 receptor agonists, CB2 receptor agonists and Chemical pages without DrugBank identifier.
Vinony links it to 7 Wikipedia language editions.
Wikidata facts
- Mass
- 369.209
Show 2 more facts
- chemical formula
- C₂₆H₂₇NO
- canonical SMILES
- CCCCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=C(C4=CC=CC=C43)CC
Sources (2)
via Wikidata · CC0
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Encyclopedic overview
3 sectionsContents
- Legal status
- See also
- References
JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46 nM at CB1 and 0.69 nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologues JWH-122 (CB1 Ki 0.69 nM) and JWH-182 (CB1 Ki 0.65 nM) respectively, and than the 4-methoxy compound JWH-081 (CB1 Ki 1.2 nM). It was discovered by and named after John W. Huffman.
JWH-210 may be neurotoxic to animals when administered in high doses.
Excerpted from Wikipedia’s “JWH-210” article, available under the CC BY-SA 4.0 licence.