KDELR2
Sign in to saveAlso known as ELP-1, ERD2.2, KDEL endoplasmic reticulum protein retention receptor 2, OI21, ELP1
ER lumen protein retaining receptor 2 is a protein that in humans is encoded by the KDELR2 gene.
Gene data
KDELR2- Name
- KDEL endoplasmic reticulum protein retention receptor 2
- Type
- protein-coding
- Position
- 6,445,953–6,484,224 (−)
- Aliases
- ELP-1, ERD2.2, OI21
- Ensembl
- ENSG00000136240
- RefSeq RNA
- NM_001100603.2, NM_006854.4
- RefSeq protein
- NP_001094073.1, NP_006845.1
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
KDEL endoplasmic reticulum protein retention receptor 2
- Symbol
- KDELR2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:6,445,953-6,484,224
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 129146
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/11014
- genomic end
- 6484190
- genomic start
- 6485584
- chromosome
- human chromosome 7
- cytogenetic location
- 7p22.1
- expressed in
- pericardium
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Clinical significance
- See also
- References
- Further reading
ER lumen protein retaining receptor 2 is a protein that in humans is encoded by the KDELR2 gene.
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, lys-asp-glu-leu (KDEL) in animal cells and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product.
Excerpted from Wikipedia’s “KDELR2” article, available under the CC BY-SA 4.0 licence.