KDELR3
Sign in to saveAlso known as ERD2L3, KDEL endoplasmic reticulum protein retention receptor 3
ER lumen protein retaining receptor 3 is a protein that in humans is encoded by the KDELR3 gene.
Gene data
KDELR3- Name
- KDEL endoplasmic reticulum protein retention receptor 3
- Type
- protein-coding
- Position
- 38,468,021–38,483,762 (+)
- Aliases
- ERD23, ERD2L3
- Ensembl
- ENSG00000100196
- RefSeq RNA
- NM_006855.4, NM_016657.3
- RefSeq protein
- NP_006846.1, NP_057839.1
This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
KDEL endoplasmic reticulum protein retention receptor 3
- Symbol
- KDELR3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:38,468,021-38,483,762
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 68533
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/11015
- genomic end
- 38879452
- genomic start
- 38468078
- chromosome
- human chromosome 22
- cytogenetic location
- 22q13.1
- expressed in
- germinal epithelium
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- Further reading
ER lumen protein retaining receptor 3 is a protein that in humans is encoded by the KDELR3 gene.
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, lys-asp-glu-leu (KDEL) in animal cells and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins. Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described.
Excerpted from Wikipedia’s “KDELR3” article, available under the CC BY-SA 4.0 licence.