KDM6B
Sign in to saveAlso known as JMJD3, lysine demethylase 6B, NEDCFSA
Lysine demethylase 6B is a protein that in humans is encoded by the KDM6B (JMJD3) gene.
Gene data
KDM6B- Name
- lysine demethylase 6B
- Type
- protein-coding
- Position
- 7,834,193–7,854,796 (+)
- Aliases
- JMJD3, NEDCFSA, NEDSST
- Ensembl
- ENSG00000132510
- RefSeq RNA
- NM_001080424.2, NM_001348716.2
- RefSeq protein
- NP_001073893.1, NP_001335645.1
The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 18945
- exact match
- identifiers.org/ncbigene/23135
- genomic end
- 7758114
- genomic start
- 7834217
- cytogenetic location
- 17p13.1
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Article
9 sectionsContents
- Regulation during differentiation
- Small molecule inhibition
- Role in pathology
- Clinical picture
- Epidemiology
- Related conditions
- Ongoing research
- References
- Further reading
Lysine demethylase 6B is a protein that in humans is encoded by the KDM6B (JMJD3) gene.
== Regulation during differentiation == KDM6B was found to be expressional increased during cardiac and endothelial differentiation of murine embryonic stem cells.