IRF4
Sign in to saveAlso known as LSIRF, MUM1, NF-EM5, SHEP8, interferon regulatory factor 4
Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene. IRF4 functions as a key regulatory transcription factor in the development of human immune cells. The expression of IRF4 is essential for the differentiation of T lymphocytes and B lymphocytes as well as certain myeloid cells. Dysregulation of the IRF4 gene can result in IRF4 functioning either as an oncogene or a tumor-suppressor, depending on the context of the modification.
Gene data
IRF4- Name
- interferon regulatory factor 4
- Type
- protein-coding
- Position
- 391,739–411,443 (+)
- Aliases
- IMD131, LSIRF, MUM1, NF-EM5, SHEP8
- Ensembl
- ENSG00000137265
- RefSeq RNA
- NM_001195286.2, NM_002460.4, NR_036585.1, NR_046000.3, XM_006715090.3
- RefSeq protein
- NP_001182215.1, NP_002451.2, XP_006715153.1, XP_047274686.1, XP_054211324.1
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
interferon regulatory factor 4
- Symbol
- IRF4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:391,739-411,443
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein IRF4 PDB 2dll.png
Show 9 more facts
- HomoloGene ID
- 1842
- found in taxon
- Homo sapiens
- genetic association
- progressive supranuclear palsy
- exact match
- identifiers.org/ncbigene/3662
- genomic end
- 411443
- genomic start
- 391739
- chromosome
- human chromosome 6
- cytogenetic location
- 6p25.3
- expressed in
- superficial temporal artery
Sources (8)
via Wikidata · CC0
~7 min read
Encyclopedic overview
13 sectionsContents
- Immune cell development
- T cell differentiation
- B cell differentiation
- Long-lived plasma cells
- Myeloid cell differentiation
- Dendritic cells (DCs)
- Macrophages
- Clinical significance
- Interactions
- See also
- References
- Further reading
- External links
Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene. IRF4 functions as a key regulatory transcription factor in the development of human immune cells. The expression of IRF4 is essential for the differentiation of T lymphocytes and B lymphocytes as well as certain myeloid cells. Dysregulation of the IRF4 gene can result in IRF4 functioning either as an oncogene or a tumor-suppressor, depending on the context of the modification.
The MUM1 symbol is also the current HGNC official symbol for melanoma associated antigen (mutated) 1 (HGNC:29641).
Excerpted from Wikipedia’s “IRF4” article, available under the CC BY-SA 4.0 licence.