L-isoleucine
thumb|Isoleucine ball and stick model spinning Isoleucine (symbol Ile or I) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO− form under biological conditions), and a hydrocarbon side chain with a branch (a central carbon atom bound to three other carbon atoms). It is classified as a non-polar, uncharged (at physiological pH), branched-chain, aliphatic amino acid. It is essential in humans, meaning the body cannot synthesi
AI overview
L-isoleucine is one of the amino acids that your body uses to build proteins, and it's one of the few amino acids humans must obtain from food because our bodies cannot make it on their own. It's a branched-chain amino acid, meaning its molecular structure has a particular shape, and it plays an important role in muscle function and energy metabolism.
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Research
19,583 papers- Strategy for improving L-isoleucine production efficiency in Corynebacterium glutamicum.Applied microbiology and biotechnology · 2019
- l-Isoleucine Administration Alleviates DSS-Induced Colitis by Regulating TLR4/MyD88/NF-κB Pathway in Rats.Frontiers in immunology · 2021
- Exploring L-isoleucine riboswitches for enhancing 4-hydroxyisoleucine production in Corynebacterium glutamicum.Biotechnology letters · 2023
- L-Isoleucine reverses hyperammonemia-induced myotube mitochondrial dysfunction and post-mitotic senescence.The Journal of nutritional biochemistry · 2024
- Construction of L-lysine-, L-threonine-, and L-isoleucine-overproducing strains of Corynebacterium glutamicum.Annals of the New York Academy of Sciences · 1996
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Article
11 sectionsContents
- Metabolism
- Biosynthesis
- Catabolism
- Metabolic diseases
- Insulin resistance
- Functions and requirement
- Synthesis
- Discovery
- See also
- References
- External links
thumb|Isoleucine ball and stick model spinning Isoleucine (symbol Ile or I) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO− form under biological conditions), and a hydrocarbon side chain with a branch (a central carbon atom bound to three other carbon atoms). It is classified as a non-polar, uncharged (at physiological pH), branched-chain, aliphatic amino acid. It is essential in humans, meaning the body cannot synthesize it. Essential amino acids are necessary in the human diet. In plants isoleucine can be synthesized from threonine and methionine. In plants and bacteria, isoleucine is synthesized from a pyruvate employing leucine biosynthesis enzymes. It is encoded by the codons AUU, AUC, and AUA.
== Metabolism ==
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Alpha-Amino acidsBranched-chain amino acidsChemical articles having a data pageChemical articles with multiple CAS registry numbersChemical articles with multiple compound IDsECHA InfoCard ID from WikidataEssential amino acidsGlucogenic amino acidsKetogenic amino acidsMultiple chemicals in an infobox that need indexingProteinogenic amino acids