latrunculin
Sign in to saveThe latrunculins are a family of natural products and toxins produced by certain sponges, including genus Latrunculia and Negombata, whence the name is derived. It binds actin monomers near the nucleotide binding cleft with 1:1 stoichiometry and prevents them from polymerizing. Administered in vivo, this effect results in disruption of the actin filaments of the cytoskeleton, and allows visualization of the corresponding changes made to the cellular processes. This property is similar to that of cytochalasin, but has a narrow effective concentration range. Latrunculin has been used to great ef
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Vinony's link graph records 13 inbound references to latrunculin, and connects out to Porifera, digital object identifier and Gulf of Aqaba.
It sits within the topics Actin inhibitors, Chemical articles with multiple CAS registry numbers and Chemical articles with multiple ChEBIs.
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~10 min read
Encyclopedic overview
13 sectionsContents
- History
- Structure
- Mechanism of action
- Metabolism
- Toxicity
- Plant
- Animal
- Human
- Lethal doses
- Applications
- Defense mechanism
- Sequestering by nudibranchs
- References
The latrunculins are a family of natural products and toxins produced by certain sponges, including genus Latrunculia and Negombata, whence the name is derived. It binds actin monomers near the nucleotide binding cleft with 1:1 stoichiometry and prevents them from polymerizing. Administered in vivo, this effect results in disruption of the actin filaments of the cytoskeleton, and allows visualization of the corresponding changes made to the cellular processes. This property is similar to that of cytochalasin, but has a narrow effective concentration range. Latrunculin has been used to great effect in the discovery of cadherin distribution regulation and has potential medical applications. Latrunculin A, a type of the toxin, was found to be able to make reversible morphological changes to mammalian cells by disrupting the actin network.
Latrunculin A: {| class="wikitable" !Molecular Formula: |C22H31NO5S |- !Molecular Weight: |421.552 g/mol |} Target and functions
Excerpted from Wikipedia’s “latrunculin” article, available under the CC BY-SA 4.0 licence.