leukocidin
Sign in to saveAlso known as leukocidins
A leukocidin is a type of cytotoxin created by some types of bacteria (Staphylococcus). It is a type of pore-forming toxin. Leukocidins fall into the category of bacterial invasin. Invasins are enzymatic secretions that help bacteria invade the host tissue to which they are attached. Although similar to exotoxins, invasins are different in two respects: they work through much less specific mechanisms than exotoxins, and their actions are generally more localized.
Key facts
- Nonhuman protein.Name
- Leukocidin E (S subunit)
- Nonhuman protein.Organism
- Staphylococcus aureus (strain NCTC 8325)
- Nonhuman protein.TaxID
- 1280
- Nonhuman protein.Symbol
- lukE
- Nonhuman protein.AltSymbols
- SAOUHSC_01955
- Nonhuman protein.EntrezGene
- 3920899
- Nonhuman protein.RefSeqProtein
- YP_500453
- Nonhuman protein.UniProt
- Q2FYW1
- Nonhuman protein.PDB
- 3ROH
- Nonhuman protein.Chromosome
- genomic
- Nonhuman protein.EntrezChromosome
- NC_007795.1
- Nonhuman protein.GenLoc_start
- 1858862
- Nonhuman protein.GenLoc_end
- 1860139
via Wikipedia infobox
Research
3,164 papers- Staphylococcal leukocidin.Annals of the New York Academy of Sciences · 1965
- Panton-Valentine leukocidin osteomyelitis in children: a growing threat.British journal of hospital medicine (London, England : 2005) · 2015
- Panton-Valentine Leukocidin-Positive CC398 MRSA in Urban Clinical Settings, the Netherlands.Emerging infectious diseases · 2023
- Host-Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity.Toxins · 2020
- Pragmatic management of Panton-Valentine leukocidin-associated staphylococcal diseases.International journal of antimicrobial agents · 2011
via PubMed
Wikidata facts
- Subclass of
- pore-forming toxin
Show 1 more fact
- exact match
- www.tcdb.org/search/result.php?tc=1.C.13
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Mechanism of action
- Subunits: S and F
- Variatiants
- Examples
- References
- External links
A leukocidin is a type of cytotoxin created by some types of bacteria (Staphylococcus). It is a type of pore-forming toxin. Leukocidins fall into the category of bacterial invasin. Invasins are enzymatic secretions that help bacteria invade the host tissue to which they are attached. Although similar to exotoxins, invasins are different in two respects: they work through much less specific mechanisms than exotoxins, and their actions are generally more localized.
Leukocidins get their names by killing ("-cide") leukocytes. Leukocidins target phagocytes, natural killer cells, dendritic cells, and T lymphocytes, and therefore affect both innate and adaptive immune responses.
Excerpted from Wikipedia’s “leukocidin” article, available under the CC BY-SA 4.0 licence.