Marinobufagenin (marinobufagin, MBG) is a cardiotonic bufadienolide steroid. It is secreted by the toad species such as Bufo marinus. It also can be found in the plasma and urine of human subjects with myocardial infarction, kidney failure, heart failure, and preeclampsia. MBG is a vasoconstrictor and a sodium–potassium adenosine triphosphatase (Na/K-ATPase) inhibitor with a high affinity for the alpha-1 isoform of the enzyme, the main isoform in the vascular wall and the kidney.
via PubMed
Marinobufagenin (marinobufagin, MBG) is a cardiotonic bufadienolide steroid. It is secreted by the toad species such as Bufo marinus. It also can be found in the plasma and urine of human subjects with myocardial infarction, kidney failure, heart failure, and preeclampsia. MBG is a vasoconstrictor and a sodium–potassium adenosine triphosphatase (Na/K-ATPase) inhibitor with a high affinity for the alpha-1 isoform of the enzyme, the main isoform in the vascular wall and the kidney.
It is produced by adrenal cortex and placenta via CYP27a1 pathway. MBG regulates the monovalent ions balance and cell homeostasis, and by binding to the Na/K-ATPase, it affects cell growth and differentiation, apoptosis, and proliferation. A novel effect of MBG is their ability to induce intracellular signaling, leading to a loss of elasticity and vascular fibrosis.
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).