LIG1
Sign in to saveAlso known as DNA ligase 1, LIGI, hLig1, IMD96
protein-coding gene in the species Homo sapiens
Gene data
LIG1- Name
- DNA ligase 1
- Type
- protein-coding
- Position
- 48,115,445–48,170,654 (−)
- Aliases
- IMD96, LIGI, hLig1
- Ensembl
- ENSG00000105486
- RefSeq RNA
- NM_000234.3, NM_001289063.2, NM_001289064.2, NM_001320970.2, NM_001320971.2
- RefSeq protein
- NP_000225.1, NP_001275992.1, NP_001275993.1, NP_001307899.1, NP_001307900.1
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
DNA replication - Homo sapiens (human)Base excision repair - Homo sapiens (human)Nucleotide excision repair - Homo sapiens (human)Mismatch repair - Homo sapiens (human)POLB-Dependent Long Patch Base Excision RepairResolution of AP sites via the multiple-nucleotide patch replacement pathwayDevelopmental BiologyTelomere MaintenanceHIV Life CycleEarly Phase of HIV Life Cycle
via MyGene.info
Wikidata facts
- Image
- Protein LIG1 PDB 1x9n.png
Show 5 more facts
- HomoloGene ID
- 197
- exact match
- identifiers.org/ncbigene/3978
- genomic end
- 48673860
- genomic start
- 48618702
- cytogenetic location
- 19q13.33
Sources (4)
via Wikidata · CC0
Connections
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