LIN28B
Sign in to saveAlso known as CSDD2, lin-28 homolog B
Lin-28 homolog B is a protein that in humans is encoded by the LIN28B gene. Lin28 is a gene found in both invertebrates and vertebrates, from worms to humans, where it regulates the timing of development from fertilization to adulthood.
Gene data
LIN28B- Name
- lin-28 RNA binding posttranscriptional regulator B
- Type
- protein-coding
- Position
- 104,936,616–105,083,332 (+)
- Aliases
- CSDD2
- Ensembl
- ENSG00000187772
- RefSeq RNA
- NM_001004317.4, NM_001410939.1, XM_006715477.3, XM_054355416.1
- RefSeq protein
- NP_001004317.1, NP_001397868.1, XP_006715540.2, XP_054211391.1
The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Wikidata facts
Show 6 more facts
- HomoloGene ID
- 47607
- exact match
- identifiers.org/ncbigene/389421
- genomic end
- 105531207
- genomic start
- 105404923
- cytogenetic location
- 6q16.3-q21
- Commons category
- LIN28B
via Wikidata · CC0
~3 min read
Article
7 sectionsContents
- Evolution
- Structure
- Tissue distribution
- Function
- Clinical significance
- References
- Further reading
Lin-28 homolog B is a protein that in humans is encoded by the LIN28B gene. Lin28 is a gene found in both invertebrates and vertebrates, from worms to humans, where it regulates the timing of development from fertilization to adulthood.
== Evolution ==