File:Neuroblastoma_rosettes.jpg · Wikimedia Commons · See Wikimedia Commons
neuroblastoma
Sign in to saveAlso known as NB, neuroblastoma (Schwannian Stroma-Poor)
Neuroblastoma (NB) is a type of cancer that forms in certain types of nerve tissue. It most frequently starts from one of the adrenal glands but can also develop in the neck, chest, abdomen, or spine. Symptoms may include bone pain, a mass in the abdomen, neck, or chest, or painless bluish lumps under the skin.
Key facts
- Medical condition (new).name
- Neuroblastoma
- Medical condition (new).image
- Neuroblastoma rosettes.jpg
- Medical condition (new).caption
- Microscopic view of a typical neuroblastoma with rosette formation
- Medical condition (new).image_size
- 300px
- Medical condition (new).field
- Neuro-oncology
- Medical condition (new).symptoms
- Bone pain, lumps
- Medical condition (new).onset
- Under 5 years old
- Medical condition (new).causes
- Genetic mutation
- Medical condition (new).diagnosis
- Tissue biopsy
- Medical condition (new).treatment
- Observation, surgery, radiation, chemotherapy, stem cell transplantation
- Medical condition (new).prognosis
- US five-year survival ~95% (< 1 year old), 68% (1–14 years old)
- Medical condition (new).frequency
- 1 in 7,000 children
- Medical condition (new).deaths
- 15% of deaths due to cancer in children
via Wikipedia infobox
Research
52,982 papers- Advancing therapy for neuroblastoma.Nature reviews. Clinical oncology · 2022
- Management of Neuroblastoma in Pediatric Patients.Surgical oncology clinics of North America · 2021
- Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome.Nature genetics · 2023
- Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma.Nature genetics · 2021
- Neuroblastoma models for insights into tumorigenesis and new therapies.Expert opinion on drug discovery · 2015
via PubMed
Wikidata facts
- Instance of
- cancer
- Subclass of
- childhood cancer
- Image
- Neuroblastoma rosettes.jpg
Show 7 more facts
- Commons category
- Neuroblastoma
- NCI Thesaurus ID
- C3270
- health specialty
- oncology
- drug or therapy used for treatment
- (RS)-cyclophosphamide
- genetic association
- ALK
- exact match
- www.orpha.net/ORDO/Orphanet_635
- on focus list of Wikimedia project
- WikiProject Medicine
Sources (7)
via Wikidata · CC0
~12 min read
Encyclopedic overview
21 sectionsContents
- Signs and symptoms
- Cause
- Diagnosis
- Biochemistry
- Imaging
- Histology
- Staging
- Screening
- Treatment
- Prognosis
- Cytogenetic profiles
- Epidemiology
- History
- Scientific research
- Preclinical models
- Treatments
- Refractory and relapsed neuroblastoma
- Electronic health records' data
- Organisations
- References
- External links
Neuroblastoma (NB) is a type of cancer that forms in certain types of nerve tissue. It most frequently starts from one of the adrenal glands but can also develop in the neck, chest, abdomen, or spine. Symptoms may include bone pain, a mass in the abdomen, neck, or chest, or painless bluish lumps under the skin.
Typically, neuroblastoma occurs due to a genetic mutation occurring in the first trimester of pregnancy. Rarely, it may be due to a mutation inherited. Environmental factors have not been found to be involved. Diagnosis is based on a tissue biopsy. Occasionally, it may be found in a baby by ultrasound during pregnancy. At diagnosis, the cancer has usually already spread. The cancer is divided into low-, intermediate-, and high-risk groups based on a child's age, cancer stage, and what the cancer looks like.
Excerpted from Wikipedia’s “neuroblastoma” article, available under the CC BY-SA 4.0 licence.