lipid biosynthetic process
Sign in to saveAlso known as GO:0008610, lipogenesis, lipid anabolism, lipid formation, lipid synthesis, lipid biosynthesis
In biochemistry, lipogenesis is the conversion of fatty acids and glycerol into fats, or a metabolic process through which acetyl-CoA is converted to triglyceride for storage in fat. Lipogenesis encompasses both fatty acid and triglyceride synthesis, with the latter being the process by which fatty acids are esterified to glycerol before being packaged into very-low-density lipoprotein (VLDL). Fatty acids are produced in the cytoplasm of cells by repeatedly adding two-carbon units to acetyl-CoA. Triacylglycerol synthesis, on the other hand, occurs in the endoplasmic reticulum membrane of cells
Research
16,352 papers- Physiological and pathological roles of lipogenesis.Nature metabolism · 2023
- Amino acid is a major carbon source for hepatic lipogenesis.Cell metabolism · 2024
- FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth.Signal transduction and targeted therapy · 2023
- De novo lipogenesis in health and disease.Metabolism: clinical and experimental · 2014
- Serine catabolism generates liver NADPH and supports hepatic lipogenesis.Nature metabolism · 2021
via PubMed
Wikidata facts
- Instance of
- biological process
- Subclass of
- lipid metabolism
Show 1 more fact
- exact match
- purl.obolibrary.org/obo/GO_0008610
Sources (3)
via Wikidata · CC0
~8 min read
Encyclopedic overview
7 sectionsContents
- Fatty acid synthesis
- Triglyceride synthesis
- Hormonal regulation
- PDH dephosphorylation
- Acetyl-CoA carboxylase
- Transcriptional regulation
- References
In biochemistry, lipogenesis is the conversion of fatty acids and glycerol into fats, or a metabolic process through which acetyl-CoA is converted to triglyceride for storage in fat. Lipogenesis encompasses both fatty acid and triglyceride synthesis, with the latter being the process by which fatty acids are esterified to glycerol before being packaged into very-low-density lipoprotein (VLDL). Fatty acids are produced in the cytoplasm of cells by repeatedly adding two-carbon units to acetyl-CoA. Triacylglycerol synthesis, on the other hand, occurs in the endoplasmic reticulum membrane of cells by bonding three fatty acid molecules to a glycerol molecule. Both processes take place mainly in liver and adipose tissue. Nevertheless, it also occurs to some extent in other tissues such as the gut and kidney. After being packaged into VLDL in the liver, the resulting lipoprotein is then secreted directly into the blood for delivery to peripheral tissues.
==Fatty acid synthesis==
Excerpted from Wikipedia’s “lipid biosynthetic process” article, available under the CC BY-SA 4.0 licence.