lipomatosis
Sign in to saveAlso known as Lipomatosis (disorder), Lipomatosis (morphologic abnormality), Launois-Bensaude Syndrome, Madelung Disease, Madelung's Disease
thumb|Mediastinal lipomatosis Lipomatosis is believed to be an autosomal dominant condition in which multiple lipomas are present on the body. Many discrete, encapsulated lipomas form on the trunk and extremities, with relatively few on the head and shoulders. In 1993, a genetic polymorphism within lipomas was localized to chromosome 12q15, where the HMGIC gene encodes the high-mobility-group protein isoform I-C. This is one of the most commonly found mutations in solitary lipomatous tumors but lipomas often have multiple mutations. Reciprocal translocations involving chromosomes 12q13 and 12q
Research
4,345 papers- Colonic Lipomatosis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021
- Multiple symmetric and multiple familial lipomatosis.Presse medicale (Paris, France : 1983) · 2021
- Syndromic lipomatosis of the head and neck: a review of the literature.Aesthetic plastic surgery · 2015
- Lipomatoses.Annales d'endocrinologie · 2024
- Multiple symmetric lipomatosis.Journal of cutaneous medicine and surgery · 2011
via PubMed
Wikidata facts
- Subclass of
- skin disease
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- on focus list of Wikimedia project
- WikiProject Medicine
- health specialty
- endocrinology
- Commons category
- Lipomatosis
- exact match
- identifiers.org/doid/DOID:3153
- ICD-9-CM
- 272.8
- NCI Thesaurus ID
- C3193
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Encyclopedic overview
4 sectionsContents
- Etymology
- See also
- References
- External links
thumb|Mediastinal lipomatosis Lipomatosis is believed to be an autosomal dominant condition in which multiple lipomas are present on the body. Many discrete, encapsulated lipomas form on the trunk and extremities, with relatively few on the head and shoulders. In 1993, a genetic polymorphism within lipomas was localized to chromosome 12q15, where the HMGIC gene encodes the high-mobility-group protein isoform I-C. This is one of the most commonly found mutations in solitary lipomatous tumors but lipomas often have multiple mutations. Reciprocal translocations involving chromosomes 12q13 and 12q14 have also been observed within.
Although this condition is benign, it can sometimes be very painful depending on location of the lipomas. Some patients who are concerned with cosmetics seek removal of individual lipomas. Removal can include simple excision, endoscopic removal, or liposuction.
Excerpted from Wikipedia’s “lipomatosis” article, available under the CC BY-SA 4.0 licence.