lonafarnib

Also known as SCH 66336, SCH-66336, SCH66336, 4-(2-{4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]piperidin-1-yl}-2-oxoethyl)piperidine-1-carboxamide

Lonafarnib, sold under the brand name Zokinvy, is a medication used to reduce the risk of death due to Hutchinson-Gilford progeria syndrome and for the treatment of certain processing-deficient progeroid laminopathies in people one year of age and older. It is under trial for its use as combination treatment for Hepatitis D Virus.

Key facts

Drug.Br: 2
Drug.Cl: 1
Drug.N: 4
Drug.O: 2
Drug.image: Lonafarnib.svg
Drug.image_class: skin-invert-image
Drug.width: 200
Drug.tradename: Zokinvy
Drug.DailyMedID: Lonafarnib
Drug.routes_of_administration: By mouth
Drug.ATC_prefix: A16
Drug.ATC_suffix: AX20
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only
Drug.CAS_number: 193275-84-2
Drug.PubChem: 148195
Drug.IUPHAR_ligand: 8024
Drug.DrugBank: DB06448

via Wikipedia infobox

Research

379 papers

Lonafarnib.2012
Lonafarnib: First Approval.Drugs · 2021
Lonafarnib Protects Against Muscle Atrophy Induced by Dexamethasone.Journal of cachexia, sarcopenia and muscle · 2025
Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.Nature communications · 2024
Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein.Signal transduction and targeted therapy · 2024

via PubMed

Wikidata facts

Mass: 636.0502281119999

Show 5 more facts

chemical formula: C₂₇H₃₁Br₂ClN₄O₂
isomeric SMILES: C1CN(CCC1CC(=O)N2CCC(CC2)[C@@H]3C4=C(C=C(C=C4CCC5=CC(=CN=C35)Br)Cl)Br)C(=O)N
canonical SMILES: C1CN(CCC1CC(=O)N2CCC(CC2)C3C4=C(C=C(C=C4CCC5=CC(=CN=C35)Br)Cl)Br)C(=O)N
World Health Organisation international non-proprietary name: lonafarnib
Commons category: Lonafarnib

Sources (2)

via Wikidata · CC0

~11 min read