Structure via PubChem · Public domain (PubChem)
luminespib
Sign in to saveAlso known as NVP-AUY922, AUY922
Luminespib (INN, previously known as NVP-AUY922) is an experimental drug candidate for the treatment of cancer. It was discovered through a collaboration between The Institute of Cancer Research and the pharmaceutical company Vernalis and licensed to Novartis. From 2011 to 2014 it was in Phase II clinical trials. Chemically it is a resorcinylic isoxazole amide
Chemical data
- Formula
- C26H31N3O5
- Molecular weight
- 465.5 g/mol
- IUPAC name
- 5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
- SMILES
- CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C
- InChIKey
- NDAZATDQFDPQBD-UHFFFAOYSA-N
- XLogP
- 3.5
- Polar surface area
- 108 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- colorectal adenocarcinoma, lymphoma, neoplasm, squamous cell lung carcinoma
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 465.226371
Show 3 more facts
- canonical SMILES
- CCNC(C=1C(C2=CC=C(C=C2)CN3CCOCC3)=C(C=4C=C(C(C)C)C(=CC4O)O)ON1)=O
- chemical formula
- C₂₆H₃₁N₃O₅
- World Health Organisation international non-proprietary name
- luminespib
Sources (6)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
{{Chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 462257909 | ImageFile = Luminespib.svg | ImageClass = skin-invert-image | ImageSize = 200px | PIN = 5-[2,4-Dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-{4-[(morpholin-4-yl)methyl]phenyl}-1,2-oxazole-3-carboxamide | OtherNames = NVP-AUY-922; AUY922; VER-52296
| Section1 =
Excerpted from Wikipedia’s “luminespib” article, available under the CC BY-SA 4.0 licence.