LZTS1

Also known as F37, FEZ1, leucine zipper, putative tumor suppressor 1, leucine zipper tumor suppressor 1

Leucine zipper putative tumor suppressor 1 is a protein that, in humans, is encoded by the LZTS1 gene.

Gene data

LZTS1

Name: leucine zipper tumor suppressor 1
Type: protein-coding
Position: 20,246,165–20,303,970 (−)
Aliases: F37, FEZ1
Ensembl: ENSG00000061337
RefSeq RNA: NM_001362884.2, NM_021020.5, XM_011544384.3, XM_011544385.3, XM_011544386.3
RefSeq protein: NP_001349813.1, NP_066300.1, XP_011542686.1, XP_011542687.1, XP_011542688.1

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009].

Gene Ontology

Biological process

negative regulation of macroautophagy regulation of synaptic plasticity regulation of dendrite morphogenesis regulation of postsynapse assembly

Molecular function

protein binding

Cellular component

cytoplasm plasma membrane postsynaptic density dendritic spine dendritic spine synapse glutamatergic synapse

via MyGene.info

Gene · Ensembl

leucine zipper tumor suppressor 1

Symbol: LZTS1
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:20,246,165-20,303,970
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 10873
exact match: identifiers.org/ncbigene/11178
found in taxon: Homo sapiens
genomic end: 20161474
genomic start: 20103676
chromosome: human chromosome 8
cytogenetic location: 8p21.3
expressed in: dorsolateral prefrontal cortex

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Encyclopedic overview

3 sections

Contents

Interactions
References
Further reading

Leucine zipper putative tumor suppressor 1 is a protein that, in humans, is encoded by the LZTS1 gene.

In melanocytic cells LZTS1 gene expression may be regulated by MITF.

Excerpted from Wikipedia’s “LZTS1” article, available under the CC BY-SA 4.0 licence.

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