Leucine zipper putative tumor suppressor 1 is a protein that, in humans, is encoded by the LZTS1 gene.
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009].
via MyGene.info
Leucine zipper putative tumor suppressor 1 is a protein that, in humans, is encoded by the LZTS1 gene.
In melanocytic cells LZTS1 gene expression may be regulated by MITF.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).