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GeneQ18028772· pop 5· linked from 14 articles

MAD2L1

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Also known as HSMAD2, MAD2, MAD2 mitotic arrest deficient-like 1 (yeast), mitotic arrest deficient 2 like 1

Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene.

Gene data

MAD2L1

Name: mitotic arrest deficient 2 like 1
Type: protein-coding
Position: 120,055,623–120,067,192 (−)
Aliases: HSMAD2, MAD2
Ensembl: ENSG00000164109
RefSeq RNA: NM_002358.4
RefSeq protein: NP_002349.1

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

mitotic spindle assembly checkpoint signaling mitotic spindle assembly checkpoint signaling mitotic spindle assembly checkpoint signaling mitotic spindle assembly checkpoint signaling negative regulation of protein catabolic process negative regulation of mitotic cell cycle regulation of nuclear division positive regulation of mitotic cell cycle spindle assembly checkpoint

Molecular function

protein binding identical protein binding protein homodimerization activity

Cellular component

chromosome, centromeric region kinetochore kinetochore kinetochore kinetochore spindle pole nucleus nucleus

Pathways

Cell cycle - Homo sapiens (human)Oocyte meiosis - Homo sapiens (human)Progesterone-mediated oocyte maturation - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Amplification of signal from the kinetochores Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Signal Transduction Cell Cycle

via MyGene.info

Gene · Ensembl

mitotic arrest deficient 2 like 1

Symbol: MAD2L1
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:120,055,623-120,067,192
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein MAD2L1 PDB 1duj.png

Show 8 more facts

exact match: identifiers.org/ncbigene/4085
HomoloGene ID: 1768
found in taxon: Homo sapiens
genomic end: 120066858
genomic start: 120055623
chromosome: human chromosome 4
cytogenetic location: 4q27
expressed in: rectum

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
Interactions
References
Further reading

Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene.

== Function ==

Excerpted from Wikipedia’s “MAD2L1” article, available under the CC BY-SA 4.0 licence.

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