BUB1B
Sign in to saveAlso known as BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1, BUB1 mitotic checkpoint serine/threonine kinase B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene. Also known as BubR1, this protein is recognized for its mitotic roles in the spindle assembly checkpoint (SAC) and kinetochore-microtubule interactions that facilitate chromosome migration and alignment. BubR1 promotes mitotic fidelity and protects against aneuploidy by ensuring proper chromosome segregation between daughter cells. BubR1 is proposed to prevent tumorigenesis.
Gene data
BUB1B- Name
- BUB1 mitotic checkpoint serine/threonine kinase B
- Type
- protein-coding
- Position
- 40,160,984–40,221,137 (+)
- Aliases
- BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1
- Ensembl
- ENSG00000156970
- RefSeq RNA
- NM_001211.6
- RefSeq protein
- NP_001202.5
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
BUB1 mitotic checkpoint serine/threonine kinase B
- Symbol
- BUB1B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:40,160,984-40,221,137
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 933
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/701
- chromosome
- human chromosome 15
- genomic start
- 40453224
- genomic end
- 40221123
- cytogenetic location
- 15q15.1
- expressed in
- trabecular bone
via Wikidata · CC0
~3 min read
Encyclopedic overview
7 sectionsContents
- Function
- Clinical Significance
- DNA repair
- Interactions
- References
- Further reading
- External links
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene. Also known as BubR1, this protein is recognized for its mitotic roles in the spindle assembly checkpoint (SAC) and kinetochore-microtubule interactions that facilitate chromosome migration and alignment. BubR1 promotes mitotic fidelity and protects against aneuploidy by ensuring proper chromosome segregation between daughter cells. BubR1 is proposed to prevent tumorigenesis.
== Function ==
Excerpted from Wikipedia’s “BUB1B” article, available under the CC BY-SA 4.0 licence.