MADCAM1
Sign in to saveAlso known as MACAM1, mucosal vascular addressin cell adhesion molecule 1
Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene. The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1.
Gene data
MADCAM1- Name
- mucosal vascular addressin cell adhesion molecule 1
- Type
- protein-coding
- Position
- 489,176–505,343 (+)
- Aliases
- MACAM1
- Ensembl
- ENSG00000099866
- RefSeq RNA
- NM_130760.3, NM_130762.3
- RefSeq protein
- NP_570116.2, NP_570118.1
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
mucosal vascular addressin cell adhesion molecule 1
- Symbol
- MADCAM1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:489,176-505,343
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- 1BQS.pdb.png
Show 8 more facts
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8174
- genomic end
- 505343
- genomic start
- 489176
- chromosome
- human chromosome 19
- cytogenetic location
- 19p13.3
- expressed in
- spleen
- Commons category
- Mucosal addressin cell adhesion molecule-1 (MADCAM-1)
via Wikidata · CC0
~3 min read
Encyclopedic overview
8 sectionsContents
- Nomenclature
- Function
- Peripheral node addressins
- Clinical significance
- See also
- References
- Further reading
- External links
Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene. The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1.
== Nomenclature ==
Excerpted from Wikipedia’s “MADCAM1” article, available under the CC BY-SA 4.0 licence.