MAGOH

Also known as MAGOH1, MAGOHA, mago homolog, exon junction complex core component, mago homolog, exon junction complex subunit

Protein mago nashi homolog is a human protein encoded by the MAGOH gene. This gene encodes the mammalian homolog of the Drosophila mago nashi gene. In mammals, mRNA expression is not limited to the germplasm, but is ubiquitous in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.

Gene data

MAGOH

Name: mago homolog, exon junction complex subunit
Type: protein-coding
Position: 53,226,890–53,238,621 (−)
Aliases: MAGOH1, MAGOHA
Ensembl: ENSG00000162385
RefSeq RNA: NM_002370.4
RefSeq protein: NP_002361.1

Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of alternative mRNA splicing, via spliceosome mRNA splicing, via spliceosome mRNA splicing, via spliceosome mRNA splicing, via spliceosome mRNA export from nucleus

Molecular function

RNA binding protein binding

Cellular component

nucleus nucleus nucleus nucleoplasm nucleoplasm spliceosomal complex cytoplasm cytosol

Pathways

RNA transport - Homo sapiens (human)mRNA surveillance pathway - Homo sapiens (human)Spliceosome - Homo sapiens (human)Developmental Biology Transport of Mature mRNA derived from an Intron-Containing Transcript Signaling by ROBO receptors Axon guidance mRNA Splicing - Major Pathway mRNA Splicing mRNA 3'-end processing

via MyGene.info

Wikidata facts

Image: The crystal structure of the human Exon Junction Complex 2J0S MAGOH.png

Show 5 more facts

HomoloGene ID: 1776
exact match: identifiers.org/ncbigene/4116
cytogenetic location: 1p32.3
genomic end: 53238518
genomic start: 53226900

Sources (4)

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Article

4 sections

Contents

In Drosophila
Interactions
References
Further reading

== In Drosophila == Drosophila flies produce unfit progeny when they have mutations in their gene. The progeny have defects in germplasm assembly and germline development.