major histocompatibility complex
Sign in to saveAlso known as MHC
set of genes for cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility
In the Vinony graph
Vinony's link graph records 549 inbound references to major histocompatibility complex, and connects out to B-cell, CD8 and mammal.
It sits within the topics Gene families, Glycoproteins and Immune system.
Vinony links it to 38 Wikipedia language editions.
Key facts
- Symbol
- HLA
- Interpro
- IPR001039
- Pdb
- IPR001039
- Alphafold
- IPR001039
via Wikipedia infobox
Research
52,360 papers- Unveiling major histocompatibility complex-mediated pan-cancer immune features by integrated single-cell and bulk RNA sequencing.Cancer letters · 2024
- Major histocompatibility complex-associated odours.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 1998
- Genomic Diversity of the Major Histocompatibility Complex in Health and Disease.Cells · 2019
- Complement C4, the Major Histocompatibility Complex, and Autoimmunity.Arthritis & rheumatology (Hoboken, N.J.) · 2022
- Soluble major histocompatibility complex molecules in immune regulation: highlighting class II antigens.Immunology · 2018
via PubMed
Wikidata facts
Show 1 more fact
- Commons category
- Major histocompatibility complex
Sources (2)
via Wikidata · CC0
~30 min read
Encyclopedic overview
The major histocompatibility complex (MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell surface proteins essential for the adaptive immune system. These cell surface proteins are called MHC molecules.
Its name comes from its discovery during the study of transplanted tissue compatibility. Later studies revealed that tissue rejection due to incompatibility is only a facet of the full function of MHC molecules, which is to bind an antigen derived from self-proteins, or from pathogens, and bring the antigen presentation to the cell surface for recognition by the appropriate T-cells. MHC molecules mediate the interactions of leukocytes, also called white blood cells (WBCs), with other leukocytes or with body cells. The MHC determines donor compatibility for organ transplant, as well as one's susceptibility to autoimmune diseases.
Excerpted from Wikipedia’s “major histocompatibility complex” article, available under the CC BY-SA 4.0 licence.