MANBA
Sign in to saveAlso known as MANB1, mannosidase beta
β-Mannosidase (}, mannanase, mannase, β-D-mannosidase, β-mannoside mannohydrolase, exo-β-D-mannanase, lysosomal β A mannosidase) is an enzyme with systematic name β-D-mannoside mannohydrolase, which is in humans encoded by the MANBA gene. This enzyme catalyses the following chemical reaction
Key facts
- Enzyme.Name
- β-Mannosidase
- Enzyme.EC_number
- 3.2.1.25
- Enzyme.CAS_number
- 9025-43-8
- Enzyme.GO_code
- 0004567
via Wikipedia infobox
Gene data
MANBA- Name
- mannosidase beta
- Type
- protein-coding
- Position
- 102,630,770–102,760,999 (−)
- Aliases
- MANB1
- Ensembl
- ENSG00000109323
- RefSeq RNA
- NM_005908.4, XM_047415692.1, XM_047415693.1, XM_047415694.1, XM_054350029.1
- RefSeq protein
- NP_005899.3, XP_047271648.1, XP_047271649.1, XP_047271650.1, XP_054206004.1
This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Wikidata facts
Show 6 more facts
- HomoloGene ID
- 4317
- exact match
- identifiers.org/ncbigene/4126
- genomic end
- 103682151
- cytogenetic location
- 4q24
- genomic start
- 102630770
- Commons category
- Beta-mannosidase
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- References
- Further reading
- External links
β-Mannosidase (}, mannanase, mannase, β-D-mannosidase, β-mannoside mannohydrolase, exo-β-D-mannanase, lysosomal β A mannosidase) is an enzyme with systematic name β-D-mannoside mannohydrolase, which is in humans encoded by the MANBA gene. This enzyme catalyses the following chemical reaction Hydrolysis of terminal, non-reducing β-D-mannose residues in β-D-mannosides
This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with β-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement.