Mevalonate kinase
Sign in to saveAlso known as mevalonate kinase 1, LH receptor mRNA-binding protein, MVK, uniprot:Q03426
mammalian protein found in Homo sapiens
In the Vinony graph
Vinony's link graph records 460 inbound references to Mevalonate kinase, and connects out to mevalonic aciduria, enzyme and steroid.
Vinony files it under EC 2.7.1, Genes on human chromosome 12 and Human proteins.
Vinony links it to 12 Wikipedia language editions.
Protein · UniProt
Mevalonate kinase
- Gene
- MVK
- Organism
- Homo sapiens (Human)
- Length
- 396 aa
- Molecular mass
- 42,451 Da
- Evidence
- 1: Evidence at protein level
Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:11278915, PubMed:18302342, PubMed:9325256, PubMed:9392419)
3D-structureATP-bindingCataractCholesterol biosynthesisCholesterol metabolismCytoplasmDisease variantKinase
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
8 registered- COMPLETEDMEVALONATE KINASE GENE MUTATIONS AND THEIR CLINICAL CORRELATIONS IN BEHÇET'S DISEASECukurova University · NCT01780363
- PHASE3COMPLETEDAn Extention Study of Safety of Canakinumab in Japanese Patients With Periodic Fever SyndromesNovartis Pharmaceuticals · NCT02911857
- PHASE2COMPLETEDCanakinumab in Patients With Active Hyper-IgD SyndromeNovartis Pharmaceuticals · NCT01303380
- RECRUITINGIlaris NIS in KoreaNovartis Pharmaceuticals · NCT06838143
- PHASE3COMPLETEDA Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis or Hereditary Periodic Fevers Who Participated in the CACZ885G2301E1, CACZ885G2306 or CACZ885N2301 StudiesNovartis Pharmaceuticals · NCT02334748
- TERMINATEDDietary Cholesterol and Defects in Cholesterol Synthesis in Mevalonate Kinase DeficiencyOregon Health and Science University · NCT00260299
Wikidata facts
- Instance of
- protein
Show 4 more facts
- found in taxon
- Homo sapiens
- cell component
- cytosol
- exact match
- purl.uniprot.org/uniprot/Q03426
- physically interacts with
- isopentenyl pyrophosphate
Sources (3)
via Wikidata · CC0
Connections
mevalonic aciduria
Entity
enzyme
Entity
steroid
Entity
PubMed
Entity
PubMed Central
Entity
Online Mendelian Inheritance in Man
Entity
Gene Ontology
Entity
Ensembl genome database project
Entity
nitrogen
Entity
phosphorus
Entity
Wikidata
Entity
alcohols
Entity
metabolism
Entity
gene
Entity
chromosome
Entity
cholesterol
Entity
digital object identifier
Entity
nucleotide
Entity
carboxylic acid
Entity
estrogen
Entity