Mevalonate kinase
Sign in to saveAlso known as mevalonate kinase 1, LH receptor mRNA-binding protein, MVK, uniprot:Q03426
mammalian protein found in Homo sapiens
Protein · UniProt
Mevalonate kinase
- Gene
- MVK
- Organism
- Homo sapiens (Human)
- Length
- 396 aa
- Molecular mass
- 42,451 Da
- Evidence
- 1: Evidence at protein level
Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:11278915, PubMed:18302342, PubMed:9325256, PubMed:9392419)
3D-structureATP-bindingCataractCholesterol biosynthesisCholesterol metabolismCytoplasmDisease variantKinase
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
8 registered- COMPLETEDMEVALONATE KINASE GENE MUTATIONS AND THEIR CLINICAL CORRELATIONS IN BEHÇET'S DISEASECukurova University · NCT01780363
- PHASE3COMPLETEDAn Extention Study of Safety of Canakinumab in Japanese Patients With Periodic Fever SyndromesNovartis Pharmaceuticals · NCT02911857
- PHASE2COMPLETEDCanakinumab in Patients With Active Hyper-IgD SyndromeNovartis Pharmaceuticals · NCT01303380
- RECRUITINGIlaris NIS in KoreaNovartis Pharmaceuticals · NCT06838143
- PHASE3COMPLETEDA Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis or Hereditary Periodic Fevers Who Participated in the CACZ885G2301E1, CACZ885G2306 or CACZ885N2301 StudiesNovartis Pharmaceuticals · NCT02334748
- TERMINATEDDietary Cholesterol and Defects in Cholesterol Synthesis in Mevalonate Kinase DeficiencyOregon Health and Science University · NCT00260299
Wikidata facts
- Instance of
- protein
Show 4 more facts
- found in taxon
- Homo sapiens
- cell component
- cytosol
- exact match
- purl.uniprot.org/uniprot/Q03426
- physically interacts with
- isopentenyl pyrophosphate
Sources (3)
via Wikidata · CC0