cytosol

Also known as cytoplasmic matrix, GO:0005829, intracellular fluid, groundplasm, ICF

thumb|right|300px|The cytosol is a crowded solution of many different types of molecules that occupy up to 30% of the cytoplasmic volume.

AI overview

The cytosol is the clear, liquid part inside cells that contains dissolved molecules and fills up to 30% of the space in the cytoplasm. It matters because many essential cellular activities happen in this crowded molecular environment, making it crucial for how cells function.

AI-generated from the Wikipedia summary — may contain errors.

Research

152,407 papers

[Cytosol malate dehydrogenase in Calicophoron ijimai trematodes and the effect of antiparasitic preparations on its activity].ReviewParazitologiia · 1983Vykhrestiuk NP, Khamatova AIu
Cytosolic and endoplasmic reticulum chaperones inhibit wt-p53 to increase cancer cells' survival by refluxing ER-proteins to the cytosol.eLife · 2025Dabsan S, Zur G, Abu-Freha N et al.DOI: 10.7554/eLife.102658
Cytosolic RNA binding of the mitochondrial TCA cycle enzyme malate dehydrogenase.RNA (New York, N.Y.) · 2024Noble M, Chatterjee A, Sekaran T et al.DOI: 10.1261/rna.079925.123
In vitro sulfonation of 7-hydroxycoumarin derivatives in liver cytosol of human and six animal species.Xenobiotica; the fate of foreign compounds in biological systems · 2020Juvonen RO, Pentikäinen O, Huuskonen J et al.DOI: 10.1080/00498254.2020.1711544
Class II MHC-restricted T cell determinants processed from either endosomes or the cytosol show similar requirements for host protein transport but different kinetics of presentation.Journal of immunology (Baltimore, Md. : 1950) · 1991Hackett CJ, Yewdell JW, Bennink JR et al.
Efficient detection of proteins retro-translocated from the ER to the cytosol by in vivo biotinylation.PloS one · 2011Petris G, Vecchi L, Bestagno M et al.DOI: 10.1371/journal.pone.0023712
The active site of yeast phosphatidylinositol synthase Pis1 is facing the cytosol.Biochimica et biophysica acta · 2015Bochud A, Conzelmann ADOI: 10.1016/j.bbalip.2015.02.006
Binding of progesterone by human uterine cytosol.The Journal of clinical endocrinology and metabolism · 1976Dyer RD, Sarto GE, Colás AEDOI: 10.1210/jcem-43-6-1211

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Wikidata facts

Image: Crowded cytosol.png

Show 2 more facts

exact match: purl.obolibrary.org/obo/GO_0005829
Commons category: Cytosol

Sources (3)

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~16 min read

Article

14 sections

Contents

Definition
Properties and composition
Water
Ions
Macromolecules
Organization
Concentration gradients
Protein complexes
Protein compartments
Biomolecular condensates
Cytoskeletal sieving
Function
References
Further reading

thumb|right|300px|The cytosol is a crowded solution of many different types of molecules that occupy up to 30% of the cytoplasmic volume.

The cytosol, also known as cytoplasmic matrix or groundplasm, is one of the liquids found inside cells (intracellular fluid (ICF)). It is separated into compartments by membranes. For example, the mitochondrial matrix separates the mitochondrion into many compartments.