miridesap
Sign in to saveAlso known as compound 52 [PMID 14998318], GSK2315698, Ro 63-8695, CPHPC, 1,1'-hexanedioyldi-D-proline
CPHPC ((R)-1-{6-[(R)-2-carboxypyrrolidin-1-yl]-6-oxohexanoyl}pyrrolidine-2-carboxylic acid) is a proline-derived small molecule able to strip amyloid P (AP) from deposits by reducing levels of circulating serum amyloid P (SAP). The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of CPHPC for amyloidosis.
Wikidata facts
- Mass
- 340.163
Show 3 more facts
- chemical formula
- C₁₆H₂₄N₂O₆
- isomeric SMILES
- C1C[C@@H](N(C1)C(=O)CCCCC(=O)N2CCC[C@@H]2C(=O)O)C(=O)O
- canonical SMILES
- C1CC(N(C1)C(=O)CCCCC(=O)N2CCCC2C(=O)O)C(=O)O
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Article
2 sectionsContents
- Mechanism
- References
CPHPC ((R)-1-{6-[(R)-2-carboxypyrrolidin-1-yl]-6-oxohexanoyl}pyrrolidine-2-carboxylic acid) is a proline-derived small molecule able to strip amyloid P (AP) from deposits by reducing levels of circulating serum amyloid P (SAP). The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of CPHPC for amyloidosis.
CPHPC has also been patented for possible treatment of Alzheimer's disease.