Structure via PubChem · Public domain (PubChem)
moxestrol
Sign in to saveAlso known as 17alpha-Ethinyl-11beta-methoxy-1,3,5(10)-estratrien-3,17-diol, 11beta-Methoxy-17alpha-ethinylestradiol
Moxestrol, sold under the brand name Surestryl, is an estrogen medication which has been used in Europe for the treatment of menopausal symptoms and menstrual disorders. It is taken by mouth. In addition to its use as a medication, moxestrol has been used in scientific research as a radioligand of the estrogen receptor.
Chemical data
- Formula
- C21H26O3
- Molecular weight
- 326.4 g/mol
- IUPAC name
- (8S,9S,11S,13S,14S,17R)-17-ethynyl-11-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
- SMILES
- C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)O)OC
- InChIKey
- MTMZZIPTQITGCY-OLGWUGKESA-N
- XLogP
- 3
- Polar surface area
- 49.7 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
135 papers- Pharmacokinetics and metabolism of moxestrol in humans.Journal of steroid biochemistry · 1983
- Radiotracers binding to estrogen receptors: I: Tissue distribution of 17 alpha-ethynylestradiol and moxestrol in normal and tumor-bearing rats.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 1982
- Pharmacokinetics and metabolism of moxestrol in animals--rat, dog and monkey.Journal of steroid biochemistry · 1983
- Metabolism of estradiol, ethynylestradiol, and moxestrol in rat uterus, vagina, and aorta: influence of sex steroid treatment.Drug metabolism and disposition: the biological fate of chemicals · 2001
- Estrogen receptor in avian embryo and adult liver: estrogen receptor activation and dissociation kinetics of estradiol, ethynylestradiol, and moxestrol.Endocrinology · 1982
via PubMed
Wikidata facts
- Mass
- 326.188
Show 4 more facts
- chemical formula
- C₂₁H₂₆O₃
- canonical SMILES
- CC12CC(C3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O)OC
- isomeric SMILES
- C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)O)OC
- subject has role
- estrogen antagonist
via Wikidata · CC0
~3 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Society and culture
- Generic names
- Brand names
- Availability
- References
Moxestrol, sold under the brand name Surestryl, is an estrogen medication which has been used in Europe for the treatment of menopausal symptoms and menstrual disorders. It is taken by mouth. In addition to its use as a medication, moxestrol has been used in scientific research as a radioligand of the estrogen receptor.
==Medical uses== Moxestrol is or has been used in the treatment of menopausal symptoms and menstrual disorders. It has been used at dosages of 50 to 150 μg per week for long-term therapy to 25 to 250 μg per day for short-term therapy.
Excerpted from Wikipedia’s “moxestrol” article, available under the CC BY-SA 4.0 licence.
Available in 8 languages
via Wikidata sitelinks · CC0