MKL1

Name

myocardin related transcription factor A

Type

protein-coding

Position

40,410,281–40,636,719 (−)

Aliases

BSAC, MAL, MKL, MKL1, MRTF-A

Ensembl

ENSG00000196588

RefSeq RNA

NM_001282660.2, NM_001282661.3, NM_001282662.3, NM_001318139.2, NM_020831.6

RefSeq protein

NP_001269589.1, NP_001269590.2, NP_001269591.2, NP_001305068.1, NP_065882.2

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].