MKL1

Also known as BSAC, MAL, MRTF-A, megakaryoblastic leukemia (translocation) 1, MKL, myocardin related transcription factor A

位於22號人類染色體的基因

In the Vinony graph

Vinony's link graph records 111 inbound references to MKL1, and connects out to PubMed, human chromosome 22 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 22.

Vinony links it to 9 Wikipedia language editions.

Gene data

MRTFA

Name: myocardin related transcription factor A
Type: protein-coding
Position: 40,410,281–40,636,726 (−)
Aliases: BSAC, MAL, MKL, MKL1, MRTF-A
Ensembl: ENSG00000196588
RefSeq RNA: NM_001282660.2, NM_001282661.3, NM_001282662.3, NM_001318139.2, NM_020831.6
RefSeq protein: NP_001269589.1, NP_001269590.2, NP_001269591.2, NP_001305068.1, NP_065882.2

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

Pathways

Signal Transduction Signaling by Rho GTPases RHO GTPase Effectors SUMOylation SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription cofactors Metabolism of proteins RHO GTPases Activate Formins Post-translational protein modification Signaling by Rho GTPases, Miro GTPases and RHOBTB3

via MyGene.info

Gene · Ensembl

myocardin related transcription factor A

Symbol: MRTFA
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:40,410,281-40,636,726
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein MKL1 PDB 2KVU.png

Show 8 more facts

HomoloGene ID: 32487
genetic association: breast cancer
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/57591
genomic end: 40636719
genomic start: 40806285
chromosome: human chromosome 22
cytogenetic location: 22q13.1-q13.2

Sources (5)

via Wikidata · CC0

Article · 中文

MKL/megakaryoblastic leukemia 1（巨核细胞白血病）是一种由人类基因 MKL1 编码的蛋白质。此基因编码的蛋白能与转录因子（英語：myocardin，一种调控平滑肌细胞分化的关键转录因子）相互作用。此蛋白主要存在于细胞核中，帮助信号从细胞质到细胞核的转导。在一个特异的染色体易位中，此基因会与1号染色体上的RNA结合基序蛋白15基因融合，这一易位与相关。

Abstract from DBpedia / Wikipedia · CC BY-SA