Myeloperoxidase
Sign in to saveAlso known as MPO, uniprot:P05164
Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. MPO is most abundantly expressed in neutrophils (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity, including hypochlorous acid, the sodium salt of which is the chemical in bleach. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation. Neutrophil myeloperoxidase has a heme pigment, which causes its green color in secretions rich in neutrophils, such as m
Key facts
- Enzyme.Name
- Myeloperoxidase
- Enzyme.EC_number
- 1.11.2.2
via Wikipedia infobox
Protein · UniProt
Myeloperoxidase
- Gene
- MPO
- Organism
- Homo sapiens (Human)
- Length
- 745 aa
- Molecular mass
- 83,869 Da
- Evidence
- 1: Evidence at protein level
Peroxidase that plays a central role in the host defense system of polymorphonuclear leukocytes by mediating both (1) formation of neutrophil extracellular trap (NETs) and (2) microbicidal activity (PubMed:16125131, PubMed:17438335, PubMed:20974672, PubMed:20974816, PubMed:22131345, PubMed:25066128, PubMed:28574339, PubMed:40963017, PubMed:4978299, PubMed:6295491). Promotes NET formation by mediating chromatin disassembly: translocates to the nucleus and specifically binds to nucleosomes, both as monomer and homodimer, leading to nucleosome unstacking and initial chromatin decondensation (P…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
55 registered- PHASE2COMPLETEDAZD3241 PET MSA Trial, Phase 2, Randomized,12 Week Safety and Tolerability Trial With PET in MSA PatientsAstraZeneca · NCT02388295
- NACOMPLETEDEffectiveness and Safety of Two Vitamin D3 Supplementation Regimens in Adults with Early-stage COVID-19Escuela Militar de Graduados de Sanidad, SEDENA · NCT06585995
- NACOMPLETEDThe Effect of Music Therapy on Glutathione Peroxidase, Malondialdehyde and Pain in Oocyt Pick Up Patients.Kahramanmaras Sutcu Imam University · NCT04175873
- NOT_YET_RECRUITINGDiagnostic Study for Differentiating Functional From Organic Diseases in Patients With Lower GIT SymptomsSohag University · NCT07016529
- PHASE1COMPLETEDStudy to Assess the Effect of AZD4831 on the Pharmacokinetics (Drug Behavior in the Body) of MidazolamAstraZeneca · NCT05052710
- PHASE3TERMINATEDImpact Of Antioxidant Micronutrients On Intensive Care Unit (ICU) OutcomeCentre Hospitalier Universitaire Vaudois · NCT00515736
Wikidata facts
- Instance of
- protein
Show 2 more facts
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P05164
via Wikidata · CC0
~7 min read
Encyclopedic overview
13 sectionsContents
- Structure
- Reaction mechanism
- Function
- Role in innate immunity
- Clinical significance
- Myeloperoxidase deficiency
- Vasculitis
- Atherosclerosis and heart disease
- Medical tests
- Inhibitors
- See also
- References
- External links
Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. MPO is most abundantly expressed in neutrophils (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity, including hypochlorous acid, the sodium salt of which is the chemical in bleach. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation. Neutrophil myeloperoxidase has a heme pigment, which causes its green color in secretions rich in neutrophils, such as mucus and sputum. The green color contributed to its outdated name verdoperoxidase.
Myeloperoxidase is found in many different organisms including mammals, birds, fish, reptiles, and amphibians. Myeloperoxidase deficiency is a well-documented disease among humans resulting in impaired immune function.
Excerpted from Wikipedia’s “Myeloperoxidase” article, available under the CC BY-SA 4.0 licence.