Proteinase 3

Protein · UniProt

Myeloblastin

Gene

PRTN3

Organism

Homo sapiens (Human)

Length

256 aa

Molecular mass

27,807 Da

Evidence

1: Evidence at protein level

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:2033050, PubMed:28240246, PubMed:3198760). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). Plays a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). Triggers inflammatory processes in neutrophils by interacting with ADGRG3 upstream of F2RL1/PAR2 activation (PubMed:36302784)

• PHASE2COMPLETED
  Safety and Tolerability Trial of Inhaled Alpha1-Proteinase Inhibitor (Human), Hydrophobic Chromatography Process (Alpha-1 HC) in Subjects With Cystic FibrosisGrifols Therapeutics LLC · NCT01684410
• PHASE2COMPLETED
  A Study of Three Anti-HIV Drug Combinations in Patients Who Have Taken AmprenavirNational Institute of Allergy and Infectious Diseases (NIAID) · NCT00001095
• PHASE2TERMINATED
  Proteinase 3 PR1 Peptide Mixed With Montanide ISA-51 VG Adjuvant and Administered With GM-CSF and PEG-INTRON(R)M.D. Anderson Cancer Center · NCT00415857
• PHASE1COMPLETED
  A Study to Assess the Bioequivalence of Darunavir When Co-Administrated With Cobicistat Under Fed and Fasted ConditionsJanssen R&D Ireland · NCT01619527
• PHASE3COMPLETED
  A Comparison of Three Anti-HIV Drug Combinations Containing Saquinavir Soft Gelatin Capsules Used in HIV-1 Infected PatientsHoffmann-La Roche · NCT00002378
• PHASE3COMPLETED
  Study Switching HIV-1 Infected Patients With an Undetectable Viral Load on a First Protease Inhibitor-Based Regimen to an Efavirenz-Based RegimenBristol-Myers Squibb · NCT00135382

via ClinicalTrials.gov

Wikidata facts

via Wikidata · CC0