MYO6

Name

myosin VI

Type

protein-coding

Position

75,749,175–75,919,537 (+)

Aliases

DFNA22, DFNB37

Ensembl

ENSG00000196586

RefSeq RNA

NM_001300899.2, NM_001368136.1, NM_001368137.1, NM_001368138.1, NM_001368139.1

RefSeq protein

NP_001287828.1, NP_001355065.1, NP_001355066.1, NP_001355067.1, NP_001355068.1

This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014].