norgestimate
Sign in to saveAlso known as ORF-10131, d-13beta-ethyl-17alpha-ethynyl-17beta-acetoxygon-4-en-3-one oxime, (17alpha)-17-(acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-oxime, (+)-13-ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one oxime acetate (ester), D-13beta-ethyl-17alpha-ethynyl-17beta-acetoxygon-4-en-3-one oxime
Norgestimate, sold under the brand name Ortho Tri-Cyclen among others, is a progestin medication which is used in birth control pills for women and in menopausal hormone therapy. The medication is available in combination with an estrogen and is not available alone. It is taken by mouth.
Research
431 papers- Norgestimate.Clinical obstetrics and gynecology · 1995
- Norgestimate: a clinical overview of a new progestin.American journal of obstetrics and gynecology · 1992
- Spotlight on estradiol and norgestimate as hormone replacement therapy in postmenopausal women.Treatments in endocrinology · 2002
- Classification and pharmacology of progestins.Maturitas · 2003
- Desogestrel, norgestimate, and gestodene: the newer progestins.The Annals of pharmacotherapy · 1995
via PubMed
Wikidata facts
- Mass
- 369.230394
Show 5 more facts
- chemical formula
- C₂₃H₃₁NO₃
- World Health Organisation international non-proprietary name
- norgestimate
- canonical SMILES
- CCC12CCC3C(C1CCC2(C#C)OC(=O)C)CCC4=CC(=NO)CCC34
- isomeric SMILES
- CC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)OC(=O)C)CCC4=C/C(=N/O)/CC[C@H]34
- Commons category
- Norgestimate
Sources (2)
via Wikidata · CC0
~15 min read
Article
21 sectionsContents
- Medical uses
- Available forms
- Contraindications
- Side effects
- Overdose
- Interactions
- Pharmacology
- Pharmacodynamics
- Progestogenic activity
- Androgenic activity
- Other activities
- Pharmacokinetics
- Chemistry
- History
- Society and culture
- Generic names
- Brand names
- Availability
- Research
- References
- Further reading
Norgestimate, sold under the brand name Ortho Tri-Cyclen among others, is a progestin medication which is used in birth control pills for women and in menopausal hormone therapy. The medication is available in combination with an estrogen and is not available alone. It is taken by mouth.
Side effects of the combination of an estrogen and norgestimate include menstrual irregularities, headaches, nausea, abdominal pain, breast tenderness, mood changes, and others. Norgestimate is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has very weak androgenic activity and no other important hormonal activity. The medication is a prodrug of norelgestromin and to a lesser extent of levonorgestrel in the body.