NOX4
Sign in to saveAlso known as KOX, KOX-1, RENOX, NADPH oxidase 4
NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases.
Gene data
NOX4- Name
- NADPH oxidase 4
- Type
- protein-coding
- Position
- 89,324,353–89,498,187 (−)
- Aliases
- KOX, KOX-1, RENOX
- Ensembl
- ENSG00000086991
- RefSeq RNA
- NM_001143836.3, NM_001143837.2, NM_001291926.2, NM_001291927.1, NM_001291929.2
- RefSeq protein
- NP_001137308.2, NP_001137309.2, NP_001278855.2, NP_001278856.1, NP_001278858.2
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 41065
- exact match
- identifiers.org/ncbigene/50507
- genomic end
- 89322779
- genomic start
- 89324353
- cytogenetic location
- 11q14.3
Sources (8)
via Wikidata · CC0
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Article
3 sectionsContents
- Function
- References
- Further reading
NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases.
== Function ==