Also known as MEA5, NCOAT, meningioma expressed antigen 5 (hyaluronidase), MGEA5, O-GlcNAcase
protein-coding gene in the species Homo sapiens
Gene data
OGA- Name
- O-GlcNAcase
- Type
- protein-coding
- Position
- 101,784,443–101,818,620 (−)
- Aliases
- MEA5, MGEA5, NCOAT
- Ensembl
- ENSG00000198408
- RefSeq RNA
- NM_001142434.2, NM_012215.5, XM_047424514.1, XM_047424515.1, XM_047424516.1
- RefSeq protein
- NP_001135906.1, NP_036347.1, XP_047280470.1, XP_047280471.1, XP_047280472.1
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008].
Gene Ontology
Biological process
Molecular function
hyalurononglucosaminidase activityhexosaminidase activityhexosaminidase activityidentical protein binding[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
via MyGene.info
Gene · Ensembl
O-GlcNAcase
- Symbol
- OGA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:101,784,443-101,818,620
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI