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organoid
EntityQ11293125· pop 23· linked from 103 articles

Also known as organoids, organoide

thumb|Intestinal organoid grown from Lgr5+ stem cells

Research

34,667 papers

via PubMed

Wikidata facts

Part of
encephalon
Material used
stem cell
Life expectancy
80
Show 1 more fact
Commons category
Organoids
Sources (4)

via Wikidata · CC0

~31 min read

Encyclopedic overview

22 sections
Contents
  • History
  • Properties
  • Process
  • Types
  • Cerebral organoid
  • Gastrointestinal organoid
  • Intestinal organoid
  • Gastric organoid
  • Liver and pancreatic organoids
  • Lingual organoid
  • Cerebellar organoid
  • Cancer organoids
  • Other
  • Basic research
  • Models of disease
  • Personalized medicine
  • Organoid transplants
  • As a model for developmental biology
  • See also
  • References
  • Further reading
  • External links

thumb|Intestinal organoid grown from Lgr5+ stem cells

An organoid is a miniaturised and simplified version of an organ produced in vitro in three dimensions that mimics the key functional, structural, and biological complexity of that organ. It is derived from one or a few cells from a tissue, embryonic stem cells, or induced pluripotent stem cells, which can self-organize in three-dimensional culture owing to their self-renewal and differentiation capacities. The technique for growing organoids has rapidly improved since the early 2010s, and The Scientist named it one of the biggest scientific advancements of 2013. Scientists and engineers use organoids to study development and disease in the laboratory, for drug discovery and development in industry, personalized diagnostics and medicine, gene and cell therapies, tissue engineering, and regenerative medicine.

Excerpted from Wikipedia’s “organoid” article, available under the CC BY-SA 4.0 licence.

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