OTUD6B
Sign in to saveAlso known as DUBA-5, DUBA5, CGI-77, OTU domain containing 6B, IDDFSDA, OTU deubiquitinase 6B
OTU domain containing 6B is a protein that in humans is encoded by the OTUD6B gene.
Gene data
OTUD6B- Name
- OTU deubiquitinase 6B
- Type
- protein-coding
- Aliases
- CGI-77, DUBA-5, DUBA5, IDDFSDA
This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells. [provided by RefSeq, Nov 2013].
via MyGene.info
Gene · Ensembl
OTU deubiquitinase 6B
- Symbol
- OTUD6B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:91,070,196-91,087,095
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 6064
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/51633
- genomic end
- 92099323
- genomic start
- 92082424
- chromosome
- human chromosome 8
- cytogenetic location
- 8q21.3
- expressed in
- ganglionic eminence
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
OTU domain containing 6B is a protein that in humans is encoded by the OTUD6B gene.
OTUD6B is a functional deubiquitinating enzyme, a class of protease that specifically cleaves ubiquitin linkages, negating the action of ubiquitin ligases. OTUD6B, also known as DUBA5, belongs to a DUB subfamily characterized by an ovarian tumor domain (OTU). OTUD6B function may be connected to growth and proliferation. This hypothesis is supported by a recent study indicating that OTUD6B knock out mice, obtained through exon 4 deletion, are subviable and smaller in size. In humans, OTUD6B mutations have been connected to an intellectual disability syndrome associated with dysmorphic features.
Excerpted from Wikipedia’s “OTUD6B” article, available under the CC BY-SA 4.0 licence.