PARK7
Sign in to saveAlso known as DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD2
DJ1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. Its weak glyoxalase activity has been verified by many labs, however the reported protein deglycase activity is likely to be an artifact stemming from DJ-1's ability to destroy free methylglyoxal.
Gene data
PARK7- Name
- Parkinsonism associated deglycase
- Type
- protein-coding
- Position
- 7,954,264–7,985,505 (+)
- Aliases
- DJ-1, DJ1, GATD2, HEL-S-67p
- Ensembl
- ENSG00000116288
- RefSeq RNA
- NM_001123377.2, NM_007262.5, XM_005263424.4, XM_054334046.1
- RefSeq protein
- NP_001116849.1, NP_009193.2, XP_005263481.1, XP_054190021.1
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Wikidata facts
- Image
- Protein PARK7 PDB 1j42.png
Show 5 more facts
- HomoloGene ID
- 38295
- exact match
- identifiers.org/ncbigene/11315
- genomic start
- 8014351
- genomic end
- 8045565
- cytogenetic location
- 1p36.23
via Wikidata · CC0
~4 min read
Article
11 sectionsContents
- Structure
- Gene
- Protein
- Function
- DNA repair
- Clinical significance
- Interactions
- See also
- References
- Further reading
- External links
DJ1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. Its weak glyoxalase activity has been verified by many labs, however the reported protein deglycase activity is likely to be an artifact stemming from DJ-1's ability to destroy free methylglyoxal.
== Structure ==