PARK7
Sign in to saveAlso known as DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD2
DJ1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. Its weak glyoxalase activity has been verified by many labs, however the reported protein deglycase activity is likely to be an artifact stemming from DJ-1's ability to destroy free methylglyoxal.
Gene data
PARK7- Name
- Parkinsonism associated deglycase
- Type
- protein-coding
- Position
- 7,952,654–7,985,991 (+)
- Aliases
- DJ-1, DJ1, GATD2, HEL-S-67p
- Ensembl
- ENSG00000116288
- RefSeq RNA
- NM_001123377.2, NM_007262.5, XM_005263424.4, XM_054334046.1
- RefSeq protein
- NP_001116849.1, NP_009193.2, XP_005263481.1, XP_054190021.1
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
Parkinsonism associated deglycase
- Symbol
- PARK7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:7,952,654-7,985,991
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PARK7 PDB 1j42.png
Show 8 more facts
- HomoloGene ID
- 38295
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/11315
- genomic start
- 8014351
- chromosome
- human chromosome 1
- genomic end
- 8045565
- cytogenetic location
- 1p36.23
- expressed in
- right ventricle
via Wikidata · CC0
~4 min read
Encyclopedic overview
11 sectionsContents
- Structure
- Gene
- Protein
- Function
- DNA repair
- Clinical significance
- Interactions
- See also
- References
- Further reading
- External links
DJ1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. Its weak glyoxalase activity has been verified by many labs, however the reported protein deglycase activity is likely to be an artifact stemming from DJ-1's ability to destroy free methylglyoxal.
== Structure ==
Excerpted from Wikipedia’s “PARK7” article, available under the CC BY-SA 4.0 licence.