methylglyoxal
Methylglyoxal (MGO) is the organic compound with the formula CH3C(O)CHO. It is a reduced derivative of pyruvic acid. It is a reactive compound that is implicated in the biology of diabetes. Methylglyoxal is produced industrially by degradation of carbohydrates using overexpressed methylglyoxal synthase.
Research
6,211 papers- Methylglyoxal.IARC monographs on the evaluation of carcinogenic risks to humans · 1991
- Methylglyoxal is an antibacterial effector produced by macrophages during infection.Cell host & microbe · 2025
- Methylglyoxal stress, the glyoxalase system, and diabetic chronic kidney disease.Current opinion in nephrology and hypertension · 2019
- Methylglyoxal Induced Modifications to Stabilize Therapeutic Proteins: A Review.The protein journal · 2024
- Methylglyoxal and Small Heat Shock Proteins.Biochemistry. Biokhimiia · 2017
via PubMed
Article
8 sectionsContents
- Chemical structure
- Biochemistry
- Biosynthesis and biodegradation
- Biochemical function
- Biomedical aspects
- Occurrence, other
- See also
- References
Methylglyoxal (MGO) is the organic compound with the formula CH3C(O)CHO. It is a reduced derivative of pyruvic acid. It is a reactive compound that is implicated in the biology of diabetes. Methylglyoxal is produced industrially by degradation of carbohydrates using overexpressed methylglyoxal synthase.
==Chemical structure== Gaseous methylglyoxal has two carbonyl groups: an aldehyde and a ketone. In the presence of water, it exists as hydrates and oligomers. The formation of these hydrates is indicative of the high reactivity of MGO, which is relevant to its biological behavior.
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Categories
Advanced glycation end-productsAldehydesChembox having GHS dataChembox image size setChemical articles with multiple CAS registry numbersChemical articles with multiple compound IDsConjugated ketonesECHA InfoCard ID from WikidataEndogenous aldehydesGABAA receptor agonistsMetabolismMultiple chemicals in an infobox that need indexing