PCBP2

Also known as HNRNPE2, HNRPE2, hnRNP-E2, poly(rC) binding protein 2

Poly(rC)-binding protein 2 is a protein that in humans is encoded by the PCBP2 gene.

Gene data

PCBP2

Name: poly(rC) binding protein 2
Type: protein-coding
Position: 53,451,900–53,484,618 (+)
Aliases: HNRNPE2, HNRPE2, hnRNP-E2
Ensembl: ENSG00000197111
RefSeq RNA: NM_001098620.3, NM_001128911.2, NM_001128912.2, NM_001128913.2, NM_001128914.2
RefSeq protein: NP_001092090.1, NP_001122383.1, NP_001122384.1, NP_001122385.1, NP_001122386.1

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018].