HNRNPK

Also known as CSBP, HNRPK, TUNP, AUKS, heterogeneous nuclear ribonucleoprotein K

Heterogeneous nuclear ribonucleoprotein K (also protein K) is a protein that in humans is encoded by the HNRNPK gene. It is found in the cell nucleus that binds to pre-messenger RNA (mRNA) as a component of heterogeneous ribonucleoprotein particles. The simian homolog is known as protein H16. Both proteins bind to single-stranded DNA as well as to RNA and can stimulate the activity of RNA polymerase II, the protein responsible for most gene transcription. The relative affinities of the proteins for DNA and RNA vary with solution conditions and are inversely correlated, so that conditions promo

Gene data

HNRNPK

Name: heterogeneous nuclear ribonucleoprotein K
Type: protein-coding
Position: 83,966,674–83,981,586 (−)
Aliases: AUKS, CSBP, HNRPK, TUNP
Ensembl: ENSG00000165119
RefSeq RNA: NM_001318186.2, NM_001318187.2, NM_001318188.2, NM_002140.5, NM_031262.4
RefSeq protein: NP_001305115.1, NP_001305116.1, NP_001305117.1, NP_002131.2, NP_112552.1

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008].