PCGF2

Name

polycomb group ring finger 2

Type

protein-coding

Position

38,733,065–38,752,555 (−)

Aliases

MEL-18, RNF110, TPFS, ZNF144

Ensembl

ENSG00000277258

RefSeq RNA

NM_001369614.1, NM_001369615.1, NM_007144.3, XM_017025016.2, XM_047436660.1

RefSeq protein

NP_001356543.1, NP_001356544.1, NP_009075.1, XP_016880505.1, XP_047292616.1

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

polycomb group ring finger 2

Symbol

PCGF2

Biotype

Protein coding

Organism

Homo sapiens

Location

17:38,733,065-38,752,555

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein PCGF2 PDB 2h0d.png

via Wikidata · CC0