PDS5B
Sign in to saveAlso known as APRIN, AS3, CG008, PDS5 cohesin associated factor B
Sister chromatid cohesion protein PDS5 homolog B (PDS5B) is a protein that in humans is encoded by the PDS5B gene. It is a regulatory subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. The core cohesin complex is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. PDS5 associates with WAPL to stimulate the release of cohesin from DNA but during DNA replication PDS5 promotes acetylation of SMC3 by ESCO1 and ESCO2.
Gene data
PDS5B- Name
- PDS5 cohesin associated factor B
- Type
- protein-coding
- Position
- 32,586,315–32,778,320 (+)
- Aliases
- APRIN, AS3, CG008
- Ensembl
- ENSG00000083642
- RefSeq RNA
- NM_015032.4, NM_015928.1, XM_005266298.5, XM_011534999.3, XM_011535000.3
- RefSeq protein
- NP_055847.1, XP_005266355.1, XP_011533301.1, XP_011533302.1, XP_011533304.1
This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
PDS5 cohesin associated factor B
- Symbol
- PDS5B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 13:32,586,315-32,778,320
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Structure of PDS5B (blue), WAPL (green) and IP6 (PDB 5HDT) (Ouyang et al., 2016).png
Show 8 more facts
- HomoloGene ID
- 41001
- genomic end
- 33352157
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23047
- genomic start
- 32586452
- chromosome
- human chromosome 13
- cytogenetic location
- 13q13.1
- expressed in
- oocyte
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Sister chromatid cohesion protein PDS5 homolog B (PDS5B) is a protein that in humans is encoded by the PDS5B gene. It is a regulatory subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. The core cohesin complex is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. PDS5 associates with WAPL to stimulate the release of cohesin from DNA but during DNA replication PDS5 promotes acetylation of SMC3 by ESCO1 and ESCO2.
==References==
Excerpted from Wikipedia’s “PDS5B” article, available under the CC BY-SA 4.0 licence.